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Showing 1–19 of 19 results
Advanced filters: Author: Pierre Léopold Clear advanced filters

  • Circulating adiponectin controls sensitivity to insulin in tissues. Here, Arquier et al. show that adiponectin receptor activity in neurons of the Drosophila brain controls insulin response in peripheral tissues via juvenile hormone signaling.

    • Nathalie Arquier
    • Marianne Bjordal
    • Pierre Léopold
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Virtually all successful treatments of cancer either create, restore or enhance the antitumour immune response. Therefore, the specific features of the immune microenvironment, both before and after treatment, are important determinants of patients' outcomes. In this Review, the authors describe the influence of the immunological characteristics of the tumour microenvironment on responses to treatment in patients with a variety of cancers.

    • Wolf H. Fridman
    • Laurence Zitvogel
    • Guido Kroemer
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 717-734

  • In this Review, Zitvogelet al. describe the mouse models of transplantable, carcinogen-induced and genetically engineered tumours that have laid the foundations of oncoimmunology.

    • Laurence Zitvogel
    • Jonathan M. Pitt
    • Guido Kroemer
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 759-773

  • The microbiota influences the development of cancer and the effect of cancer therapies. In this Review, the authors summarize the interactions between the microbiota, the immune system and tumours and how manipulation of the microbiota can be used therapeutically.

    • Laurence Zitvogel
    • Romain Daillère
    • Guido Kroemer
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 465-478

  • Autophagy is fundamental to cellular homeostasis and also has a central role in the development and progression of cancer. However, autophagy is also required for optimal immune system function, including the development of an anticancer immune response. In this Perspective, the authors present the available preclinical and clinical evidence that autophagy might enhance the effectiveness of both immunogenic chemotherapy and radiotherapy, as opposed to the general view of inhibition of autophagy as an antitumour strategy.

    • Lorenzo Galluzzi
    • José Manuel Bravo-San Pedro
    • Guido Kroemer
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 247-258

  • Chronic kidney disease (CKD) affects numerous organs and systems, which in turn have effects on kidney function. This Review provides an overview of CKD as a systemic disease and discusses the multidirectional links between the kidney, bone, nervous and immune systems, and metabolism.

    • Carmine Zoccali
    • Raymond Vanholder
    • Gerard London
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 344-358

  • Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?

    • Lorenzo Galluzzi
    • Aitziber Buqué
    • Guido Kroemer
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 97-111

  • Dysregulated autophagy is associated with a variety of conditions, including cancer, neurodegenerative diseases, cardiovascular disorders and infectious diseases. However, despite significant efforts, no specific modulators of autophagy have yet been moved into the clinic. Here, Galluzziet al. discuss the therapeutic potential of autophagy modulators and consider the key challenges that have limited their development.

    • Lorenzo Galluzzi
    • José Manuel Bravo-San Pedro
    • Guido Kroemer
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 487-511

  • Whether autophagy — an intracellular degradation pathway — contributes to or protects against damage following different types of acute brain injury is unclear. Here, Kroemer and colleagues review investigations into the effects of autophagy in excitotoxicity, acute exposure to neurotoxins, neonatal asphyxia, stroke and neurotrauma.

    • Lorenzo Galluzzi
    • José Manuel Bravo-San Pedro
    • Guido Kroemer
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 467-484