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The emerging roles of microvesicles in liver diseases

Microvesicles—extracellular vesicles released by virtually all cells—are now implicated in key processes of liver diseases including fibrosis and complications of cirrhosis and hepatocellular carcinoma. This Review describes studies assessing circulating microvesicle levels in patients with liver diseases, together with an insight into the mechanisms that could account for these changes. The potential of microvesicles as biomarkers in liver diseases is also discussed.

Sara Lemoinne
Dominique Thabut
Pierre-Emmanuel Rautou
Reviews04 Feb 2014
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 350-361
Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension

Constance de Margerie-Mellon
Florian Joly
Bernard E. Van Beers
ResearchOpen Access16 Jan 2026
Scientific Reports

P: 1-13
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

JAK2V617F mutation is associated with an increased risk for athero-thrombotic cardiovascular disease, but its role in aortic disease development remains unknown. Here, the authors show that JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.

Rida Al-Rifai
Marie Vandestienne
Hafid Ait-Oufella
ResearchOpen Access03 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Loss of fenestrae in liver sinusoidal endothelial cells contributes to MASLD

Liver sinusoidal endothelial cells have small pores called fenestrae that allow bidirectional exchange of substrates such as lipids between hepatocytes and blood. New work reveals molecular pathways linking hyperlipidemia to these cells’ loss of fenestrae as a starting point for metabolic dysfunction-associated steatotic liver disease.

Nadia Ciriaci
Pierre-Emmanuel Rautou
Johanne Poisson
News & Views14 Jun 2024
Nature Cardiovascular Research

Volume: 3, P: 622-624
Author Correction: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Rida Al-Rifai
Marie Vandestienne
Hafid Ait-Oufella
Amendments and CorrectionsOpen Access23 Dec 2022
Nature Communications

Volume: 13, P: 1
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory phenotype in macrophages and myofibroblasts and proliferation of the latter.

Pushpa Hegde
Emmanuel Weiss
Sophie Lotersztajn
ResearchOpen Access01 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Extracellular vesicles in coronary artery disease

Extracellular vesicles regulate the transfer of biological information, acting locally and remotely. Interest in extracellular vesicles, in particular exosomes, in the cardiovascular field emerged a decade ago, opening new research and therapeutic avenues. This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents.

Chantal M. Boulanger
Xavier Loyer
Nicolas Amabile
Reviews02 Feb 2017
Nature Reviews Cardiology

Volume: 14, P: 259-272
Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness

Shvetank Sharma
Jaswinder S. Maras
Shiv K. Sarin
ResearchOpen Access28 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Venous thrombosis and predictors of relapse in eosinophil-related diseases

Valériane Réau
Alexandre Vallée
Matthieu Groh
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

Gemma Odena
Jiegen Chen
Ramon Bataller
ResearchOpen Access18 Oct 2016
Scientific Reports

Volume: 6, P: 1-15
ACBP/DBI neutralization for the experimental treatment of fatty liver disease

Omar Motiño
Flavia Lambertucci
Guido Kroemer
ResearchOpen Access16 Nov 2024
Cell Death & Differentiation

Volume: 32, P: 434-446
Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia

Alexandre Nuzzo
Kevin Guedj
Aminata Souare
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-10

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The emerging roles of microvesicles in liver diseases

Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Loss of fenestrae in liver sinusoidal endothelial cells contributes to MASLD

Author Correction: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Extracellular vesicles in coronary artery disease

Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness

Venous thrombosis and predictors of relapse in eosinophil-related diseases

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

ACBP/DBI neutralization for the experimental treatment of fatty liver disease

Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia

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