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Showing 1–2 of 2 results
Advanced filters: Author: Pierre-Henri Moreau Clear advanced filters

  • A base-editing approach optimized to target the retina shows high editing rates in a mouse model of Stargardt disease, as well as in nonhuman primates and ex vivo human retinal explants, paving the way for potential clinical applications.

    • Alissa Muller
    • Jack Sullivan
    • Bence György
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 490-501

  • A pentavalent live attenuated vaccine platform, MOPEVACNEW, was engineered to express glycoproteins from all five known pathogenic New World arenaviruses from a modified Mopeia virus. This approach induces robust antiviral antibody responses and sterile protection to prevent severe haemorrhagic fever and mortality in cynomolgus monkeys.

    • Stéphanie Reynard
    • Xavier Carnec
    • Sylvain Baize
    Research
    Nature Microbiology
    Volume: 8, P: 64-76