Nature Search

Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19

The authors use an agent-based model to investigate the potential of reactive vaccination strategies for COVID-19 outbreak mitigation. They find that distributing vaccines in schools and workplaces where cases are detected is more impactful than non-reactive strategies in a wide range of epidemic scenarios.

Benjamin Faucher
Rania Assab
Chiara Poletto
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-11
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Cystic fibrosis imposes a decline in quality of life but new treatments are being developed that target specificCFTRvariants. Here the authors identify five genome loci significantly associated with variation in disease severity in a meta-analysis, which may provide targets for individualized treatment of cystic fibrosis.

Harriet Corvol
Scott M. Blackman
Michael R. Knowles
ResearchOpen Access29 Sept 2015
Nature Communications

Volume: 6, P: 1-8
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Underdetection of cases of COVID-19 in France threatens epidemic control

Analyses of virological and surveillance data in France show that a substantial proportion of symptomatic cases of COVID-19 have remained undetected and that easily accessible and efficient testing is required to control the pandemic.

Giulia Pullano
Laura Di Domenico
Vittoria Colizza
Research21 Dec 2020
Nature

Volume: 590, P: 134-139
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

Lisa Strug and colleagues report a genome-wide association study for meconium ileus in individuals with cystic fibrosis. Conventional genome-wide approaches identified variants in SLC26A9 and SLC6A14 associated with meconium ileus. The authors also performed a hypothesis-driven genome-wide association study (HD-GWAS) that upweighted 3,814 SNPs within 10 kb of 155 genes expressed in the apical plasma membrane. The HD-GWAS identified variants near SLC9A3 associated with meconium ileus.

Lei Sun
Johanna M Rommens
Lisa J Strug
Research01 Apr 2012
Nature Genetics

Volume: 44, P: 562-569
Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic

Di Domenico and Sabbatini et al. model the impact of lockdowns of varying duration and intensity on the control of COVID-19, using data from the third wave of the epidemic in the Paris region of France. The authors introduce a measure of policy-induced fatigue, the ‘distress index’, that helps to explain why shorter, more stringent restrictions might be more effective.

Laura Di Domenico
Chiara E. Sabbatini
Vittoria Colizza
ResearchOpen Access06 Dec 2021
Communications Medicine

Volume: 1, P: 1-13
Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains

Ousmane Oumou Diallo
Sophie Alexandra Baron
Jean-Marc Rolain
ResearchOpen Access26 Oct 2020
Scientific Reports

Volume: 10, P: 1-9

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