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Showing 1–4 of 4 results
Advanced filters: Author: Pietro B Carrieri Clear advanced filters

  • The metabolic requirements of T cells vary according to their functional state. Matarese and colleagues show that the most functionally active human regulatory T cells are highly glycolytic and that this directly controls expression of a distinct splice variant of the transcription factor Foxp3.

    • Veronica De Rosa
    • Mario Galgani
    • Giuseppe Matarese
    Research
    Nature Immunology
    Volume: 16, P: 1174-1184

  • The adipocyte-derived hormone leptin provides a link between metabolic status and the immune system, and has been implicated in the pathogenesis of autoimmune disorders such as multiple sclerosis (MS). Matarese et al. review clinical and molecular evidence for an association between leptin and MS disease activity, and consider the prospects for metabolic and nutritional interventions in the treatment of this condition.

    • Giuseppe Matarese
    • Pietro Biagio Carrieri
    • Antonio La Cava
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 455-461

  • The suppressive function and number of regulatory T cells (Treg cells) is reduced in autoimmune disease. Here, Giuseppe Matarese and colleagues report that Treg cell proliferation is reduced in subjects with relapsing-remitting multiple sclerosis. As disease severity increases, Treg cell proliferation progressively decreases and is associated with impaired IL-2 release and IL-2 receptor and mTOR signaling.

    • Fortunata Carbone
    • Veronica De Rosa
    • Giuseppe Matarese
    Research
    Nature Medicine
    Volume: 20, P: 69-74