Flavivirus infection leads to a rearrangement of host cell ER membranes that creates an environment permissive to viral replication. The morphology of these membrane rearrangements is known, but the mechanisms involved are unclear. Here, atlastins—ER-resident membrane-bound GTPases of the dynamin family—are shown to be targeted by flaviviruses to establish their replication organelle and for virion maturation and secretion.
- Christopher J. Neufeldt
- Mirko Cortese
- Ralf Bartenschlager
