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Showing 1–7 of 7 results
Advanced filters: Author: Pimchai Chaiyen Clear advanced filters

  • Flavin-dependent halogenases catalyse the challenging regioselective halogenation of aromatic compounds, but display low efficiency. Now, a tryptophan-halogenase with multiple catalytic improvements is obtained by engineering the intermediate transfer tunnel connecting the enzyme´s two active sites.

    • Kridsadakorn Prakinee
    • Aisaraphon Phintha
    • Pimchai Chaiyen
    Research
    Nature Catalysis
    Volume: 5, P: 534-544

  • Biocatalysts have many benefits for speeding up specific transformations, but the chemistry used by naturally occurring catalysts is limited. Pioneering work in 2016 used directed evolution to create heme-dependent enzymes able to form new silicon–carbon bonds, showcasing the approach’s power to attain catalysts capable of new-to-nature chemistry.

    • Kridsadakorn Prakinee
    • Pimchai Chaiyen
    News & Views
    Nature Chemical Biology
    Volume: 21, P: 32-34

  • Biocatalysis needs improved reproducibility and quality of research reporting. Our interdisciplinary team has developed a flexible and extensible metadata catalogue based on STRENDA guidelines, essential for describing complex experimental setups in biocatalysis. The catalogue is available online via GitHub for community use.

    • Stephan Malzacher
    • Dominik Meißner
    • Dörte Rother
    Comments & Opinion
    Nature Catalysis
    Volume: 7, P: 1245-1249

  • The specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA with high sensitivity and specificity in hundreds of nasopharyngeal and throat swab samples collected at Siriraj Hospital in Thailand.

    • Maturada Patchsung
    • Krittapas Jantarug
    • Chayasith Uttamapinant
    Research
    Nature Biomedical Engineering
    Volume: 4, P: 1140-1149

  • Renilla luciferase is a popular bioluminescent enzyme, but the molecular details of its mechanism of action on luciferins such as coelenterazine remained elusive. Now, protein crystal structures and biochemical analyses provide an atomistic description of its catalytic mechanism.

    • Andrea Schenkmayerova
    • Martin Toul
    • Martin Marek
    Research
    Nature Catalysis
    Volume: 6, P: 23-38