Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Pinelopi Moutzouri Clear advanced filters

  • Proteolysis targeting chimeras (PROTACs) promote the degradation of targets by ensuring the proximity of the E3-ligase and the target, and understanding the structure of PROTACs at the atomic level is key to developing more efficient degraders. Here the authors determine the complete atomic-level structure of an amorphous Von Hippel-Lindau (VHL)-based SMARCA2 PROTAC (PROTAC 2).

    • Daria Torodii
    • Jacob B. Holmes
    • Lyndon Emsley
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The atomic-level ensemble structure of an amorphous form of a drug is determined by combining NMR experiments with molecular dynamics simulations and machine-learned chemical shifts. The structure explains the stabilization of the amorphous form.

    • Manuel Cordova
    • Pinelopi Moutzouri
    • Lyndon Emsley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12