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Nature Immunology (2)

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Advanced filters: Author: Pingyan Cheng Clear advanced filters

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Phosphorylation-dephosphorylation and ubiquitination tune TCR signaling to avoid self-reactivity. Kim and colleagues show that acetylation also modulates TCR signaling.

Imene Hamaidi
Pingyan Cheng
Sungjune Kim
ResearchOpen Access29 Jan 2026
Nature Immunology

P: 1-12
Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

Gabrilovich and colleagues show that monocytic myeloid-derived suppressor cells (MDSCs) differentiate into polymorphonuclear MDSCs in individuals with tumors, demonstrating a demonstrating a distinct regulation of myeloid cell development in cancer.

Je-In Youn
Vinit Kumar
Dmitry I Gabrilovich
Research27 Jan 2013
Nature Immunology

Volume: 14, P: 211-220

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SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

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