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Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells

Ubhi et al. describe the contribution of APOBEC family members A3C and A3D in the gemcitabine resistance mechanism in the context of pancreatic cancer, which is mediated by facilitating the restart of treatment-induced stalled replication forks.

Tajinder Ubhi
Olga Zaslaver
Grant W. Brown
Research06 Mar 2024
Nature Cancer

Volume: 5, P: 895-915
Picosecond infrared laser mass spectrometry for 10-second identification of lymphoproliferative imposter tumours in patient-derived xenografts

Lan-Anna Ye
Darah Vlaminck
Arash Zarrine-Afsar
ResearchOpen Access07 Jan 2026
Scientific Reports

Volume: 16, P: 1-12
Modeling response to the KRAS-G12C inhibitor AZD4625 in KRAS^G12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms

Joshua C. Rosen
Pinjiang Cao
Ming-Sound Tsao
ResearchOpen Access11 Oct 2025
British Journal of Cancer

Volume: 134, P: 165-174