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Showing 1–3 of 3 results
Advanced filters: Author: Piul Rabbani Clear advanced filters

  • On wounding, scar formation in mammals arises causing no hair follicle regeneration, but it is unclear if scarring precludes regeneration. Here, the authors show that if Sonic hedgehog signaling is activated in the wound, an inductive dermal niche forms, enabling regeneration and hair follicle formation.

    • Chae Ho Lim
    • Qi Sun
    • Mayumi Ito
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Nail stem cells (NSCs) reside in the proximal nail matrix, and early nail progenitors undergo Wnt-dependent differentiation into the nail; after amputation, Wnt activation is required for nail and digit regeneration, and amputations proximal to the Wnt-active nail progenitors fail to regenerate, but β-catenin stabilization in the NSC region induces regeneration.

    • Makoto Takeo
    • Wei Chin Chou
    • Mayumi Ito
    Research
    Nature
    Volume: 499, P: 228-232

  • Mayumi Ito and her colleagues show that during skin wounding in mice, melanocyte stem cells in the hair follicle are induced by melanocortin 1 receptor (Mc1r) signaling to migrate towards the epidermis and differentiate into mature pigment-producing cells. This mechanism allows for protection of the healing skin from ultraviolet light–induced damage.

    • Wei Chin Chou
    • Makoto Takeo
    • Mayumi Ito
    Research
    Nature Medicine
    Volume: 19, P: 924-929