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Nature Nanotechnology (1)

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Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

Rationally designed polymer vesicles increase cytosolic delivery of cGAMP, activating the STING pathway and increasing the immunogenicity of the tumour microenvironment in in vivo murine models of melanoma and in human metastatic melanoma tissues.

Daniel Shae
Kyle W. Becker
John T. Wilson
Research21 Jan 2019
Nature Nanotechnology

Volume: 14, P: 269-278

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Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

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