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Showing 51–55 of 55 results
Advanced filters: Author: Po-Ru Loh Clear advanced filters

  • Christian Fuchsberger, Gonçalo Abecasis and colleagues describe a new web-based imputation service that enables rapid imputation of large numbers of samples and allows convenient access to large reference panels of sequenced individuals. Their state space reduction provides a computationally efficient solution for genotype imputation with no loss in imputation accuracy.

    • Sayantan Das
    • Lukas Forer
    • Christian Fuchsberger
    Research
    Nature Genetics
    Volume: 48, P: 1284-1287

  • Hilary Finucane, Brendan Bulik-Sullivan, Benjamin Neale, Alkes Price and colleagues introduce a new method, called stratified LD score regression, for partitioning heritability by functional category using genome-wide association study summary statistics. They observe a substantial enrichment of heritability in conserved regions and illustrate how this approach can provide insights into the biological basis of disease and direction for functional follow-up.

    • Hilary K Finucane
    • Brendan Bulik-Sullivan
    • Alkes L Price
    Research
    Nature Genetics
    Volume: 47, P: 1228-1235

  • Brendan Bulik-Sullivan, Benjamin Neale, Hilary Finucane, Alkes Price and colleagues introduce a new technique for estimating genetic correlation that requires only genome-wide association summary statistics and that is not biased by sample overlap. Using this method, they find genetic correlations between anorexia nervosa and schizophrenia, and between educational attainment and autism spectrum disorder.

    • Brendan Bulik-Sullivan
    • Hilary K Finucane
    • Benjamin M Neale
    Research
    Nature Genetics
    Volume: 47, P: 1236-1241

  • Steven Gazal, Alkes Price and colleagues extend stratified LD score regression to continuous annotations. They analyze summary statistics from 56 complex diseases and traits and find that SNPs with low levels of linkage disequilibrium have larger per-SNP heritability, consistent with the action of negative selection on deleterious variants that affect complex traits.

    • Steven Gazal
    • Hilary K Finucane
    • Alkes L Price
    Research
    Nature Genetics
    Volume: 49, P: 1421-1427