Nature Search

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4⁺ T cells is seeded within the first 2 days after infection.

James B. Whitney
So-Yon Lim
Dan H. Barouch
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-8
Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus

Neural mechanisms underlying circadian photoentrainment are not fully understood. Using in vivo two-photon imaging with a GRIN lens, this study reveals a dynamic bi-stable circuit in the suprachiasmatic nucleus that regulates light-driven circadian clock shifts, providing insight into mechanisms of circadian photoentrainment.

Po-Ting Yeh
Kai-Chun Jhan
Shih-Kuo Chen
ResearchOpen Access08 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy

Combining expansion microscopy (ExM) with lightsheet imaging can enable fast 3D visualisation of biological structures at high-resolution, but such approaches can be hindered by several limitations. By using potassium acrylate-based hydrogels, the authors perform large-volume ExM with Bessel lightsheet microscopy, achieving high-resolution imaging of cellular structures within the fly brain.

Xuejiao Tian
Tzu-Yang Lin
Bi-Chang Chen
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-16
GeneAgent: self-verification language agent for gene-set analysis using domain databases

GeneAgent is a language agent using large language models and self-verification to improve gene-set function annotation.

Zhizheng Wang
Qiao Jin
Zhiyong Lu
ResearchOpen Access28 Jul 2025
Nature Methods

Volume: 22, P: 1677-1685
Benchmarking large language models for biomedical natural language processing applications and recommendations

Baseline performance, benchmarks, and guidance for LLMs in biomedicine are limited. The authors assess four LLMs on 12 tasks, establish baselines, examine hallucinations, and provide recommendations for optimal LLM use.

Qingyu Chen
Yan Hu
Hua Xu
ResearchOpen Access06 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Overcoming the energy gap law in near-infrared OLEDs by exciton–vibration decoupling

Pt(ii) complexes allow the fabrication of efficient near-infrared organic light-emitting diodes that operate beyond the 900 nm region.

Yu-Chen Wei
Sheng Fu Wang
Pi-Tai Chou
Research29 Jun 2020
Nature Photonics

Volume: 14, P: 570-577
Relationship between genotype, phenotype, and refractive status in patients of inherited retinal degeneration

Wan-Chen Tsai
Yao-Lin Liu
Ta-Ching Chen
Research02 Aug 2024
Eye

Volume: 38, P: 3301-3308
Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Jeng-Long Hsieh
Po-Chuan Shen
Shih-Yao Chen
ResearchOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

Bo-Ching Lee
Yu-Ling Chang
Ying-Ying Chen
ResearchOpen Access14 Oct 2024
Hypertension Research

Volume: 48, P: 519-528
Dynamic weight bearing analysis is effective for evaluation of tendinopathy using a customized corridor with multi-directional force sensors in a rat model

Po-Ting Wu
Chieh-Hsiang Hsu
Li-Chieh Kuo
ResearchOpen Access18 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer’s disease

Po-Ting Chen
Zih-ten Chen
Rita P.-Y. Chen
ResearchOpen Access13 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Optimizing adrenal vein sampling in primary aldosteronism subtyping through LC–MS/MS and secretion ratios of aldosterone, 18-oxocortisol, and 18-hydroxycortisol

Yu-Ling Chang
Guan-Yuan Chen
Yen-Hung Lin
ResearchOpen Access13 Jun 2023
Hypertension Research

Volume: 46, P: 1983-1994
Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging

Ueh-Ting Tim Wang
Xuejiao Tian
Bi-Chang Chen
ResearchOpen Access08 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors

Kuo-Ting Chen
Po-Ting Chen
Wei-Chieh Cheng
ResearchOpen Access17 Aug 2016
Scientific Reports

Volume: 6, P: 1-11
Radiomics utilization to differentiate nonfunctional adenoma in essential hypertension and functional adenoma in primary aldosteronism

Po-Ting Chen
Dawei Chang
Yen-Hung Lin
ResearchOpen Access25 May 2022
Scientific Reports

Volume: 12, P: 1-9
High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy

Po-Ting Wu
Li-Chieh Kuo
I-Ming Jou
ResearchOpen Access16 Jan 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus

Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy

GeneAgent: self-verification language agent for gene-set analysis using domain databases

Benchmarking large language models for biomedical natural language processing applications and recommendations

Overcoming the energy gap law in near-infrared OLEDs by exciton–vibration decoupling

Relationship between genotype, phenotype, and refractive status in patients of inherited retinal degeneration

Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

Dynamic weight bearing analysis is effective for evaluation of tendinopathy using a customized corridor with multi-directional force sensors in a rat model

Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer’s disease

Optimizing adrenal vein sampling in primary aldosteronism subtyping through LC–MS/MS and secretion ratios of aldosterone, 18-oxocortisol, and 18-hydroxycortisol

Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging

Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors

Radiomics utilization to differentiate nonfunctional adenoma in essential hypertension and functional adenoma in primary aldosteronism

High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy

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