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Showing 1–5 of 5 results
Advanced filters: Author: Polina V. Lishko Clear advanced filters

  • Here they show that the essential sperm calcium channel CatSper is temperature-gated and reversibly inhibited by spermine. This discovery uncovers a key regulatory mechanism of sperm function and highlights the critical role of testicular cooling in male fertility.

    • Dilip K. Swain
    • Citlalli Vergara
    • Polina V. Lishko
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Progesterone stimulates an increase in Ca2+ levels in human sperm, but the underlying signalling mechanism is poorly understood. Two studies now show that progesterone activates the sperm-specific, pH-sensitive CatSper calcium channel, leading to a rapid influx of Ca2+ ions into the spermatozoa. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives.

    • Polina V. Lishko
    • Inna L. Botchkina
    • Yuriy Kirichok
    Research
    Nature
    Volume: 471, P: 387-391

  • The flagella of mammalian sperm display non-planar, asymmetric beating, but the molecular basis is unclear. Chen et al. performed in situ cryo-ET of mouse and human sperm and discovered asymmetric distributions of regulatory complexes that could generate asymmetric bending force.

    • Zhen Chen
    • Garrett A. Greenan
    • Ronald D. Vale
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 360-369

  • Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sperm tail.

    • Yanhe Zhao
    • Huafeng Wang
    • Jean-Ju Chung
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15