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Showing 1–3 of 3 results
Advanced filters: Author: Pooja Jadiya Clear advanced filters

  • Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

    • Alyssa A. Lombardi
    • Andrew A. Gibb
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Na+ controls the function of the mitochondrial oxidative phosphorylation system and hypoxic redox signalling through an unexpected interaction with phospholipids.

    • Pablo Hernansanz-Agustín
    • Carmen Choya-Foces
    • Antonio Martínez-Ruiz
    Research
    Nature
    Volume: 586, P: 287-291

  • Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2+ exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.

    • Pooja Jadiya
    • Devin W. Kolmetzky
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14