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Showing 1–3 of 3 results
Advanced filters: Author: Pooja Keshavan Clear advanced filters

  • Ribosomes are prime targets for antibiotics in pathogenic bacteria. Here, cryo-electron microscopy reveals features in the Borrelia burgdorferi ribosome that provide insights into ribosome evolution, dormancy, and antibiotic binding.

    • Manjuli R. Sharma
    • Swati R. Manjari
    • Nilesh K. Banavali
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Translation within mitochondria is carried out by specialized mitoribosomes and translational factors. Here the authors describe cryo-EM structures of the human mitochondrial translation elongation factor G1 in complex with human mitoribosomes, revealing distinct mechanism that include conformational changes at the polypeptide exit tunnel.

    • Ravi Kiran Koripella
    • Manjuli R. Sharma
    • Rajendra K. Agrawal
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • High-resolution cryo-EM structures and biochemical analyses of the human mitoribosome, in complex with mitochondria-specific factors mediating mitoribosome recycling, RRFmt and EF-G2mt, offer insight into mechanisms of mitoribosome recycling and resistance to antibiotic fusidic acid.

    • Ravi Kiran Koripella
    • Ayush Deep
    • Rajendra K. Agrawal
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13