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Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers

Metastatic triple negative breast cancer (mTNBC) has limited treatments options. Here, this group presents a combination of low-dose cyclophosphamide, anti-CSF1R, and anti-PD-1 therapies to boost immune cell infiltration and reduce recurrence in aggressive TNBC models.

Diego A. Pedroza
Xueying Yuan
Jeffrey M. Rosen
ResearchOpen Access03 Jan 2026
Nature Communications

P: 1-20
Unmasking the notion of ‘Supermom’ in India: success and strain amongst earning mothers

Shalaka Sharad Shah
Poonam Gandhi
Smita Chaudhry
ResearchOpen Access30 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Na_v1.6 complex in nucleus accumbens neurons

Protein/protein interaction (PPI) interfaces have emerged as drug targets to develop medications with less side effects. Here, Dvorak et al. show that small molecule targeting of PPIs in the brain is an approach for psychiatric drug discovery.

Nolan M. Dvorak
Paul A. Wadsworth
Fernanda Laezza
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-27
Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

Andrew A. Badachhape
Laxman Devkota
Ketan B. Ghaghada
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS

Hui J. Wang
Chang Seok Lee
Susan L. Hamilton
ResearchOpen Access09 Oct 2020
Nature Communications

Volume: 11, P: 1-20

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Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers

Unmasking the notion of ‘Supermom’ in India: success and strain amongst earning mothers

Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons

Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

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Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Na_v1.6 complex in nucleus accumbens neurons