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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

scDRS associates individual cells in scRNA-seq with disease by scoring single-cell transcriptomes using GWAS gene signatures. Applied to 74 GWAS and 1.3 million single-cell profiles, scDRS identifies specific cellular subpopulations associated with these diseases.

Martin Jinye Zhang
Kangcheng Hou
Alkes L. Price
Research01 Sept 2022
Nature Genetics

Volume: 54, P: 1572-1580
Publisher Correction: Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Amendments and CorrectionsOpen Access28 Mar 2022
Nature Biotechnology

Volume: 40, P: 974
Cell types of origin of the cell-free transcriptome

Cell types affected by various diseases are inferred from cell-free RNA.

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
ResearchOpen Access07 Feb 2022
Nature Biotechnology

Volume: 40, P: 855-861

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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Publisher Correction: Cell types of origin of the cell-free transcriptome

Cell types of origin of the cell-free transcriptome

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