Nature Search

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Max L. Valenstein
Pranav V. Lalgudi
David M. Sabatini
Research08 Jan 2025
Nature

Volume: 637, P: E11-E14
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Xin Gu
Patrick Jouandin
David M. Sabatini
Amendments and Corrections13 Sept 2022
Nature

Volume: 609, P: E11
Structural basis for the dynamic regulation of mTORC1 by amino acids

Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.

Max L. Valenstein
Maximilian Wranik
Kacper B. Rogala
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 493-500
Discovery and engineering of the antibody response to a prominent skin commensal

Staphylococcus epidermidis induces a potent, durable and specific antibody response that is conserved in humans and non-human primates, and which could be redirected against pathogens as a new form of topical vaccination.

Djenet Bousbaine
Katherine D. Bauman
Michael A. Fischbach
Research11 Dec 2024
Nature

Volume: 638, P: 1054-1064
Mouse lemur cell atlas informs primate genes, physiology and disease

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Camille Ezran
Shixuan Liu
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 185-196
A molecular cell atlas of mouse lemur, an emerging model primate

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Antoine de Morree
Iwijn De Vlaminck
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 173-184
Structure of the nutrient-sensing hub GATOR2

The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

Max L. Valenstein
Kacper B. Rogala
David M. Sabatini
Research13 Jul 2022
Nature

Volume: 607, P: 610-616
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Fruitflies require Sestrin to regulate mTORC1 signalling in response to dietary leucine, survive a diet low in leucine, and control leucine-sensitive physiological characteristics, which establishes Sestrin as a physiologically relevant leucine sensor.

Xin Gu
Patrick Jouandin
David M. Sabatini
Research20 Jul 2022
Nature

Volume: 608, P: 209-216
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

Genome editing technologies enable the rapid interrogation of genetic alterations. Here, the authors present a CRISPR/Cas9-based platform to simultaneously investigate multiple activating point mutations in de novo cancers in mice; and generate panels of Kras-variants in different tissues to induce cancer.

Ian P. Winters
Shin-Heng Chiou
Monte M. Winslow
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-16

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Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Structural basis for the dynamic regulation of mTORC1 by amino acids

Discovery and engineering of the antibody response to a prominent skin commensal

Mouse lemur cell atlas informs primate genes, physiology and disease

A molecular cell atlas of mouse lemur, an emerging model primate

Structure of the nutrient-sensing hub GATOR2

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

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