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Showing 1–4 of 4 results
Advanced filters: Author: Prashanth Rajarajan Clear advanced filters

  • Schahram Akbarian and colleagues report that mutation of the gene encoding the SETDB1 (KMT1E) histone methyltransferase in mouse neurons leads to dissolution of chromosome conformations and a topologically associated domain at the clustered protocadherin locus. They show that SETDB1 prevents excess CTCF binding and is important for maintaining developmentally important higher-order chromatin organization.

    • Yan Jiang
    • Yong-Hwee Eddie Loh
    • Schahram Akbarian
    Research
    Nature Genetics
    Volume: 49, P: 1239-1250

  • Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D structure in the brain, which is also observed by comparison of mouse strains with recent retrotransposon expansion.

    • Sandhya Chandrasekaran
    • Sergio Espeso-Gil
    • Schahram Akbarian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Promoter–enhancer loopings and other features of the 3D genome are dynamically regulated in the brain. In this Review, Akbarian and colleagues discuss how neuronal and glial gene expression is governed by the 3D genome, with implications for cognition and neuropsychiatric disease.

    • Prashanth Rajarajan
    • Sergio Espeso Gil
    • Schahram Akbarian
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 681-691