Here the authors made lipid-based CCR5-receptor targeted nanoparticles to facilitate cell-based delivery of the antiretroviral drug rilpivirine, improving HIV-1 suppression in cell and tissue reservoirs. Focused ultrasound facilitates penetrance of the nanoparticles across the blood-brain barrier where they enter myeloid cells in humanized mice.
- Milankumar Patel
- Sudipta Panja
- Howard E. Gendelman
