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Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

Chemokine receptors are G protein-coupled receptors (GPCRs) involved in immune responses and characterized by ligand promiscuity Here, the authors characterize signaling through chemokine receptors CXCR4 and CXCR7, with insights into intrinsic-bias encoded in the CXCR4-CXCR7 system.

Parishmita Sarma
Carlo Marion C. Carino
Arun K. Shukla
ResearchOpen Access09 Aug 2023
Nature Communications

Volume: 14, P: 1-17
An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides

Solvent shielding of the amide hydrogen bond donor through chemical modification or conformational control has been successfully utilized to impart membrane permeability to macrocyclic peptides. Here, the authors show that passive membrane permeability can also be conferred by masking the amide hydrogen bond acceptor through thioamide substitution, leading to improved pharmacological properties of peptide macrocycles.

Pritha Ghosh
Nishant Raj
Jayanta Chatterjee
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Prevalence of malaria in two highly endemic Community Health Centers in the Bastar district, Chhattisgarh showing mixed infections with Plasmodium species

Sri Krishna
Ajay Yadav
Neeru Singh
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

A synthetic antibody fragment can disrupt the interaction of a GPCR regulatory protein β-arrestin with clathrin, and thereby inhibit induced internalization of GPCRs.

Eshan Ghosh
Ashish Srivastava
Arun K. Shukla
Research02 Oct 2017
Nature Nanotechnology

Volume: 12, P: 1190-1198
CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

5-HT₂ and corticotrophin releasing factor (CRF) receptors both regulate stress responses and anxiety behavior; however, potential cross-talk between the two pathways is poorly understood. Magalhaes et al. find that CRF receptor activation causes cell-surface recruitment of constitutively internalized 5-HT₂ receptor and that this mechanism is relevant to anxiety-related behaviors.

Ana C Magalhaes
Kevin D Holmes
Stephen S G Ferguson
Research11 Apr 2010
Nature Neuroscience

Volume: 13, P: 622-629
Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

In this study, the authors reveal distinct developmental programs underlying innate and learned olfactory behaviors by demonstrating that chemogenetic inactivation of neurons generated in neonatal mice impairs the behavioral response to aversive odorants, whereas inactivation of adult-born neurons impairs learning of novel food-related odors.

Nagendran Muthusamy
Xuying Zhang
H Troy Ghashghaei
Research05 Dec 2016
Nature Neuroscience

Volume: 20, P: 20-23
Toxic cultures: e-cigarettes and the oral microbial exposome

Michelle Lee-Scott Beverly
Prem Prashant Chaudhary
Purnima S. Kumar
ResearchOpen Access26 Apr 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-12
Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants

Ratley, Zeldin et al. implicate xylene in the pathogenesis of atopic dermatitis by combining spatial analysis and patient surveys with prior epidemiological and mechanistic data. They propose that exposure of healthy skin commensals to xylene, benzene and isocyantes in synthetic fabrics disrupts normal lipid metabolism and activates itching.

Grace Ratley
Jordan Zeldin
Ian A. Myles
ResearchOpen Access18 Apr 2024
Communications Medicine

Volume: 4, P: 1-10
Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression

Shalini Dogra
Ajeet Kumar
Prem N. Yadav
ResearchOpen Access16 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Prem N Yadav
Atheir I Abbas
Bryan L Roth
Research03 Nov 2010
Neuropsychopharmacology

Volume: 36, P: 638-651
Successful cloning of a superior buffalo bull

Naresh L. Selokar
Papori Sharma
Prem Singh Yadav
ResearchOpen Access06 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
A rapid colorimetric LAMP assay for detection of Rhizoctonia solani AG-1 IA causing sheath blight of rice

Prassan Choudhary
Pallavi Rai
Anil Kumar Saxena
ResearchOpen Access16 Dec 2020
Scientific Reports

Volume: 10, P: 1-19
The miRNA and PD-1/PD-L1 signaling axis: an arsenal of immunotherapeutic targets against lung cancer

Ritu Yadav
Rinku Khatkar
Aklank Jain
ReviewsOpen Access29 Sept 2024
Cell Death Discovery

Volume: 10, P: 1-19
A Gα_s DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

Martilias S Farrell
Ying Pei
Bryan L Roth
Research05 Dec 2012
Neuropsychopharmacology

Volume: 38, P: 854-862

Search

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides

Prevalence of malaria in two highly endemic Community Health Centers in the Bastar district, Chhattisgarh showing mixed infections with Plasmodium species

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Toxic cultures: e-cigarettes and the oral microbial exposome

Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants

Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Successful cloning of a superior buffalo bull

A rapid colorimetric LAMP assay for detection of Rhizoctonia solani AG-1 IA causing sheath blight of rice

The miRNA and PD-1/PD-L1 signaling axis: an arsenal of immunotherapeutic targets against lung cancer

A Gα_s DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

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