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Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing

Attaching a syndecan-binding domain to vascular endothelial and platelet-derived growth factor variants enhances their binding to syndecans and triggers tonic signalling for enhanced bone regeneration and wound repair in mice.

Mayumi Mochizuki
Esra Güç
Mikaël M. Martino
Research04 Nov 2019
Nature Biomedical Engineering

Volume: 4, P: 463-475
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models.

Jun Ishihara
Ako Ishihara
Jeffrey A. Hubbell
ResearchOpen Access04 Jun 2018
Nature Communications

Volume: 9, P: 1-14
Design principles for therapeutic angiogenic materials

Angiogenesis is mediated by cytokines that function in concert with the extracellular matrix as a biofunctional physiological materials system. By analysing this system, design rules can be identified for biomimetic synthetic materials systems to induce therapeutic angiogenesis.

Priscilla S. Briquez
Lindsay E. Clegg
Jeffrey A. Hubbell
Reviews11 Jan 2016
Nature Reviews Materials

Volume: 1, P: 1-15
VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone

Andrea Grosso
Alexander Lunger
Nunzia Di Maggio
ResearchOpen Access13 Mar 2023
npj Regenerative Medicine

Volume: 8, P: 1-15
Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

Jialu Liu
Ani Solanki
Priscilla S. Briquez
ResearchOpen Access30 Jun 2022
npj Regenerative Medicine

Volume: 7, P: 1-11
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes

Michael J. V. White
Priscilla S. Briquez
Jeffrey A. Hubbell
ResearchOpen Access18 Nov 2021
npj Regenerative Medicine

Volume: 6, P: 1-12

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Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Design principles for therapeutic angiogenic materials

VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone

Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes

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