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Showing 1–4 of 4 results
Advanced filters: Author: Priya Bellare Clear advanced filters

  • Small RNAs can silence target genes by a variety of pathways and mechanisms. Specific microRNAs have now been shown to partition into distinct effector complexes, which may in turn affect their silencing output.

    • Priya Bellare
    • Erik J Sontheimer
    News & Views
    Nature Structural & Molecular Biology
    Volume: 14, P: 684-686

  • The Hermansky-Pudlak Syndrome 4 protein (HPS4) mediates trafficking between late endosomes and lysosomes and is now shown to inhibit small RNA-mediated silencing (RNAi) in flies and human cells. Components of the ESCRT complex, which mediates late endosome trafficking, are required for efficient miRNA-mediated silencing and additional results support the idea that RNAi effectors are functionally linked to endosome-associated compartments.

    • Young Sik Lee
    • Sigal Pressman
    • Richard W. Carthew
    Research
    Nature Cell Biology
    Volume: 11, P: 1150-1156