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Showing 1–4 of 4 results
Advanced filters: Author: Puneet Juneja Clear advanced filters

  • Endosomal recycling relies on SNX17 to transport membrane proteins via Retriever. Here, authors reveal the mechanisms of SNX17 autoinhibition and its interaction with Retriever, uncovering a broader family of factors with similar binding strategies.

    • Amika Singla
    • Daniel J. Boesch
    • Baoyu Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an arginine clasp interaction motif, and report the cryo-EM structures of seven designed nanotubes.

    • Fengbin Wang
    • Ordy Gnewou
    • Vincent P. Conticello
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The study presents a high-resolution structure of the retriever complex and a model of the retriever–CCC assembly, providing a mechanistic framework for studying how retriever facilitates endosomal recycling of diverse membrane proteins.

    • Daniel J. Boesch
    • Amika Singla
    • Ezra Burstein
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 910-924

  • Respiratory syncytial virus (RSV) is a pathogenic non-segmented negative-sense RNA virus and active RSV polymerase is composed of a 250 kDa large (L) protein and tetrameric phosphoprotein (P). Here, the authors present the 3.67 Å cryo-EM structure of the RSV polymerase (L:P) complex.

    • Dongdong Cao
    • Yunrong Gao
    • Bo Liang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9