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Showing 1–2 of 2 results
Advanced filters: Author: Purushotham Selvakumar Clear advanced filters

  • The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the mechanisms of Kv1.3 gating and modulation.

    • Purushotham Selvakumar
    • Ana I. Fernández-Mariño
    • Joel R. Meyerson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The metabotropic glutamate receptors (mGluRs) are neuromodulator class C GPCRs. Here, authors characterize ligand-evoked activation and internalization of mGluRs to reveal bias in signaling and motivate structural determination of activation pathway intermediate states.

    • Alexa Strauss
    • Alberto J. Gonzalez-Hernandez
    • Joshua Levitz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17