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Showing 1–3 of 3 results
Advanced filters: Author: Pyoung Hwa Park Clear advanced filters

  • CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.

    • Sergey Karakashev
    • Hengrui Zhu
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Bitler et al. show that HDAC6 activity is essential for the survival of ovarian cancer cells carrying loss-of-function ARID1A mutation, thus representing a promising therapeutic target.

    • Benjamin G. Bitler
    • Shuai Wu
    • Rugang Zhang
    Research
    Nature Cell Biology
    Volume: 19, P: 962-973