Nature Search

Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity

Here the authors identify a tumor immunoevasion mechanism in which tumor cells release branched-chain amino acid metabolites that can bind and activate Notch on tumor-associated macrophages, reprogramming these cells to be immunosuppressive.

Qi-Xiang Ma
Ru Zhao
Qun-Ying Lei
Research14 Apr 2026
Nature Immunology

P: 1-15
Chiral aldehyde-nickel dual catalysis enables asymmetric α−propargylation of amino acids and stereodivergent synthesis of NP25302

The combination of transition metal catalysis and organocatalysis can afford both good reactivity and selectivity. Here, the authors present an α − propargylation of N-unprotected amino acid esters with propargylic alcohol derivatives via dual nickel and chiral aldehyde catalysis.

Fang Zhu
Chao-Xing Li
Qi-Xiang Guo
ResearchOpen Access26 Nov 2022
Nature Communications

Volume: 13, P: 1-9
Catalytic asymmetric Tsuji–Trost α−benzylation reaction of N-unprotected amino acids and benzyl alcohol derivatives

The catalytic asymmetric benzylations of prochiral nucleophiles are very limited. Here, the authors disclose an asymmetric α−benzylation of N-unprotected amino acids with benzyl alcohol derivatives by a chiral aldehyde-involved catalytic system.

Jian-Hua Liu
Wei Wen
Qi-Xiang Guo
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-11
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

Ma et al. show that acetylation of PRDM16 via acetyl-CoA, derived from branched-chain keto acids, impairs PRDM16–PPAR interaction, thus linking the BCAA–BCKA axis to the regulation of white adipose tissue browning.

Qi-Xiang Ma
Wen-Ying Zhu
Qun-Ying Lei
Research24 Jan 2022
Nature Metabolism

Volume: 4, P: 106-122
Diastereodivergent chiral aldehyde catalysis for asymmetric 1,6-conjugated addition and Mannich reactions

Chiral aldehyde catalysis is a useful strategy in the catalytic asymmetric α-functionalization of amino methyl compounds but these reaction types are limited. Here, the authors report two chiral aldehyde-catalysed diastereodivergent reactions, namely, a 1,6-conjugate addition and a bio-inspired Mannich reaction.

Wei Wen
Ming-Jing Luo
Qi-Xiang Guo
ResearchOpen Access23 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Zhen Wang
Fan-lian Zeng
Jiong Li
ResearchOpen Access20 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-17
Narazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models

Tao Yang
Hang Ke
Qi-Xiang Li
ResearchOpen Access19 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models

Hang Ke
Faming Zhang
Qi-Xiang Li
ResearchOpen Access03 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment

Ying Jin
Xiaoyu An
Xuesong Ouyang
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-18

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