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Showing 1–6 of 6 results
Advanced filters: Author: Qianghui Zhou Clear advanced filters

  • Methods for the direct construction of 1,3-disubstituted planar chiral ferrocenes are elusive. Now, a modular platform enables the construction of planar chirality in 1,3-disubstituted ferrocenes/ruthenocenes via enantioselective relay remote C–H arylation. The strategy involves an initial enantiodetermining ortho-C‒H activation enabled by a Pd(II)/chiral amino-acid ligand, followed by relay to the remote meta-position by a bridgehead-substituted norbornene mediator.

    • Lan Zhou
    • Hong-Gang Cheng
    • Qianghui Zhou
    Research
    Nature Chemistry
    Volume: 15, P: 815-823

  • C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.

    • Junlin Wang
    • Yanan Zhang
    • Qianghui Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • C14-functionalized steroids are pharmaceutically valuable, but their synthesis is challenging. Now a chemoenzymatic route is reported featuring a key biocatalytic C14α-hydroxylation, enabled by protein engineering of a C14α-hydroxylase (CYP14A) from Cochliobolus lunatus. Dehydration and olefin functionalization of the biocatalytic reaction products provides C14-functionalized steroids.

    • Fuzhen Song
    • Mengmeng Zheng
    • Xudong Qu
    Research
    Nature Synthesis
    Volume: 2, P: 729-739

  • Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.

    • Yong Shang
    • Chenggui Wu
    • Qianghui Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11