Crinkler effectors were believed to exist only in pathogens. Here, the authors uncover a Crinkler‑derived genomic parasite that ADP‑ribosylates EZH2 and TRAF6 to evade epigenetic silencing and immune detection, revealing an evolutionary role for toxin‑derived proteins.
- Tianjun Xu
- Shang Geng
- Yuena Sun
