Nature Search

Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle

The functional relevance of lysine crotonylation in cancer remains to be further explored. Here, the authors show that hypoxia-induced downregulation of PGK1 lysine crotonylation promotes glycolysis and suppresses mitochondrial pyruvate metabolism, contributing to breast cancer progression.

Zihao Guo
Yang Zhang
Chuanzhen Yang
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Author Correction: STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Hongxu Xian
Qiaoyun Yang
Yih-Cherng Liou
Amendments and CorrectionsOpen Access16 Nov 2021
Nature Communications

Volume: 12, P: 1
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress

Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during tumour growth.

Xuewei Zhai
Ronghui Yang
Binghui Li
Research02 Jan 2025
Nature Cell Biology

Volume: 27, P: 141-153
Microbial potential to mitigate neurotoxic methylmercury accumulation in farmlands and rice

Toxic methylmercury in soil can accumulate in rice grains. Here, the authors use DNA stable-isotope probing and metagenomics to identify soil microbes and pathways potentially involved in methylmercury degradation.

Xin-Quan Zhou
Kang-Hua Chen
Yu-Rong Liu
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-13
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence

Yang, Zhao, Wang and colleagues identify and characterize a pyrimidine biosynthetic complex pyrimidinosome that is regulated by AMP-activated protein kinase and facilitates dihydroorotate dehydrogenase-mediated ferroptosis resistance, thereby regulating cancer cell proliferation and survival.

Chuanzhen Yang
Yiliang Zhao
Binghui Li
Research08 Jun 2023
Nature Cell Biology

Volume: 25, P: 836-847
Anti-CD38 monoclonal antibody CM313 for systemic lupus erythematosus: a randomized, double-blind, placebo-controlled phase Ib/IIa trial

Jiuliang Zhao
Changsong Lin
Xiaofeng Zeng
ResearchOpen Access26 Nov 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-10
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

Reductive stress, reflected by the elevated intracellular NADH/NAD⁺ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD⁺ and NADPH/NADP⁺, and identify purine biosynthesis as an NADH-sensing pathway to mediate reductive stress.

Ronghui Yang
Chuanzhen Yang
Binghui Li
ResearchOpen Access17 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Metabolic coupling between soil aerobic methanotrophs and denitrifiers in rice paddy fields

Microbial denitrification in rice paddy fields reduces N use efficiency. Here, the authors use field samples from major rice producing areas in China and identify microbial taxa involved in the metabolic couplings between aerobic CH₄ oxidation and denitrification in rice paddy fields.

Kang-Hua Chen
Jiao Feng
Yu-Rong Liu
ResearchOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1-15
Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1

An Liu
Xingcan Li
Wei Xie
ResearchOpen Access24 Nov 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Adipocyte tissue macrophages (ATM) are recruited and activated in obesity. The authors show that adipocytes release lactate as a signal of inflammation and that this metabolite can enhance obesity associated inflammation through stimulation of ATM by direct binding with PHD2.

Tianshi Feng
Xuemei Zhao
Xiaoyan Hui
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-14
The impact of digital education on household allocation of risky financial assets in China

Ruoxuan Huang
Qinghong Shuai
Qiaoyun Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the reductive pathway to dihyroorotate which is then secreted by the cells and that such pathway is necessary for tumor growth.

Yuanyuan Wang
Changsen Bai
Binghui Li
ResearchOpen Access14 Jan 2019
Nature Communications

Volume: 10, P: 1-14
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.

Hongxu Xian
Qiaoyun Yang
Yih-Cherng Liou
ResearchOpen Access03 May 2019
Nature Communications

Volume: 10, P: 1-17
NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al. show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation.

Chenyu Li
Chenyi Xue
Yih-Cherng Liou
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-14
Pin1At regulates PIN1 polar localization and root gravitropism

Asymmetric transport of auxin allows plants to orient growth of their roots towards gravity. Here, the authors show that the peptidyl-prolyl cis/transisomerase Pin1At contributes to root gravitropism and propose that it acts by altering the polarity of the PIN1 auxin transport protein.

Wanyan Xi
Ximing Gong
Yih-Cherng Liou
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-10
Bidirectional Mendelian randomization study reveals interplay between multisite chronic pain and Post-traumatic stress disorder

Zheng Chen
Qiaoyun Yang
Tuochao Peng
ResearchOpen Access03 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG

Min Yang
Chun-Hui Gao
Zheng-Guo He
ResearchOpen Access10 Sept 2015
Scientific Reports

Volume: 5, P: 1-15
Microbial communities play important roles in modulating paddy soil fertility

Xuesong Luo
Xiaoqian Fu
Qiaoyun Huang
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells

Rui Zhang
Jing-Jing Hong
Yih-Cherng Liou
Research12 Dec 2018
Oncogene

Volume: 38, P: 2750-2766
The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females

Jun Zhao
Xu Zhang
Xu Ma
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity

Chenyu Li
Yajun Zhang
Yih-Cherng Liou
ResearchOpen Access06 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Bacillus subtilis biofilm development in the presence of soil clay minerals and iron oxides

Wenting Ma
Donghai Peng
Peng Cai
ResearchOpen Access09 Feb 2017
npj Biofilms and Microbiomes

Volume: 3, P: 1-9

Search

Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle

Author Correction: STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress

Microbial potential to mitigate neurotoxic methylmercury accumulation in farmlands and rice

De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence

Anti-CD38 monoclonal antibody CM313 for systemic lupus erythematosus: a randomized, double-blind, placebo-controlled phase Ib/IIa trial

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

Metabolic coupling between soil aerobic methanotrophs and denitrifiers in rice paddy fields

Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1

Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

The impact of digital education on household allocation of risky financial assets in China

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

Pin1At regulates PIN1 polar localization and root gravitropism

Bidirectional Mendelian randomization study reveals interplay between multisite chronic pain and Post-traumatic stress disorder

InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG

Microbial communities play important roles in modulating paddy soil fertility

Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells

The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females

NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity

Bacillus subtilis biofilm development in the presence of soil clay minerals and iron oxides

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