Macrophages undergo profound metabolic changes upon bacterial infection, including facilitated transport of the anti-bacterial metabolite Itaconate across the plasma membrane and membranes of vacuoles that contain the invading bacteria. Here authors identify MCT1/4 as transporters of itaconate, responsible for the regulation of intracellular and bacteria-containing vacuoles and thus macrophage antibacterial function in a Salmonella model of infection.
- Qingcai Meng
- Chengxi Li
- Meixin Chen
