Gao et al demonstrate that the angiogenesis regulator leucine-rich-alpha-2-glycoprotein 1 (LRG-1) links biomechanics to pathological angiogenesis in skin fibrosis progression. They find that LRG-1 is induced by the transcription factor ELK-1, which is activated through FAK and ERK signalling in response to mechanical force.
- Ya Gao
- Jia Zhou
- Qingfeng Li