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Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Tianyao Li
Jingxin Zhang
Yuhong Cao
ResearchOpen Access30 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial

Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.

Zijing Liang
Si Liu
Chuanlin Wang
ResearchOpen Access08 Jul 2025
Nature Medicine

Volume: 31, P: 2673-2681
Boron-doped sodium layered oxide for reversible oxygen redox reaction in Na-ion battery cathodes

The irreversible oxygen redox reaction during charging to the high-voltage region causes cathode structural degradation and Na-ion cell capacity fading. Here, the authors report a B-doped cathode active material to mitigate the irreversible oxygen oxidation and increase the cell capacity.

Yu-Jie Guo
Peng-Fei Wang
Yu-Guo Guo
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-11
A micro-patterned transient UV photodetector enabled by solvent-free microfabrication

Zhiqing Xu
Qinhua Guo
Yunda Wang
ResearchOpen Access20 Aug 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-11
Long non-coding RNA TUG1/microRNA-187-3p/TESC axis modulates progression of pituitary adenoma via regulating the NF-κB signaling pathway

Rui Zhang
Fan Yang
Tao Song
ResearchOpen Access21 May 2021
Cell Death & Disease

Volume: 12, P: 1-12

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Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release

Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial

Boron-doped sodium layered oxide for reversible oxygen redox reaction in Na-ion battery cathodes

A micro-patterned transient UV photodetector enabled by solvent-free microfabrication

Long non-coding RNA TUG1/microRNA-187-3p/TESC axis modulates progression of pituitary adenoma via regulating the NF-κB signaling pathway

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