Two inhibitors of death receptor-associated apoptosis, cellular c-FLIP and viral v-FLIP prevents LC3 processing by Atg3 and thus repress the autophagic cell death that follows mTOR inhibition. Short peptides derived from FLIP can prevent Atg3–FLIP interaction without affecting Atg3–LC3, restoring cell death.
- Jong-Soo Lee
- Qinglin Li
- Jae U. Jung
