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Showing 1–2 of 2 results
Advanced filters: Author: Qinya Xie Clear advanced filters
  • The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.

    • Fabian Zech
    • Daniel Schniertshauer
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Analysis of the ability of Spike proteins from 26 human or animal coronaviruses (CoVs) to use ACE2 receptors across nine reservoir, potential intermediate, and human hosts reveals determinants of ACE2 receptor usage for diverse CoVs.

    • Qingxing Wang
    • Sabrina Noettger
    • Frank Kirchhoff
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-12