Nature Search

CT-based radiomics and deep learning models for predicting thyroid cartilage invasion and patient prognosis in laryngeal carcinoma

Xinwei Chen
Shuang Xia
Juan Peng
ResearchOpen Access17 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Compact RNA editors with natural miniature Cas13j nucleases

Li, Cheng, Yu and colleagues have discovered a Cas13j family, including the compact and highly efficient LepCas13j (529 aa) and ChiCas13j (424 aa), with promising applications in RNA editing in vivo.

Guo Li
Yaxian Cheng
Yuan Yao
Research19 Sept 2024
Nature Chemical Biology

Volume: 21, P: 280-290
Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome

Endothelial Sirtuin1 downregulation in metabolic disorders causes vascular dysfunction and inflammation. Here, the authors show that deficiency of endothelial Sirtuin1, while having deleterious effects on the vasculature, stimulates skeletal muscle insulin sensitivity and improves glucose disposal.

Qiuxia Li
Quanjiang Zhang
Kaikobad Irani
ResearchOpen Access11 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity

Most miniature Cas12f nucleases have T-rich PAM specificity, restricting their targeting scopes. The cryo-EM structure of the Clostridium novyi Cas12f1 reveals the molecular basis for rare C-rich PAM recognition and enables optimization of sgRNA scaffold to improve CnCas12f1 activity.

Mengjiao Su
Fan Li
Quanjiang Ji
Research11 Sept 2023
Nature Chemical Biology

Volume: 20, P: 180-189
Programmed genome editing by a miniature CRISPR-Cas12f nuclease

Miniature CRISPR-AsCas12f1 has been biochemically characterized and engineered as an effective genome-editing tool for bacteria and human cells.

Zhaowei Wu
Yifei Zhang
Quanjiang Ji
Research02 Sept 2021
Nature Chemical Biology

Volume: 17, P: 1132-1138
Development of a versatile nuclease prime editor with upgraded precision

Strategies to improve the specificity of nuclease-based prime editor (PEn) are needed. Here the authors report a 53BP1-inhibitory ubiquitin variant-assisted PEn platform (uPEn) to inhibit NHEJ and enable precise prime editing for generation of insertions, deletions and replacements.

Xiangyang Li
Guiquan Zhang
Xingxu Huang
ResearchOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1-13
Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1

The large size of nucleases of commonly used CRISPR-Cas systems reduces the delivery efficiency of these gene-editing tools for therapeutic applications. Now, the cryo-electron microscopy structure of the miniature Acidibacillus sulfuroxidans Cas12f1 reveals the determinants for its activity despite its small size.

Zhaowei Wu
Dongliang Liu
Quanjiang Ji
Research31 Jul 2023
Nature Catalysis

Volume: 6, P: 695-709
Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

The development of selective ClpP activators targeting only the MRSA isolates without interfering with the human variant is currently challenging. Here, the authors report on the structure-based design of enantiomers of ZG197 and identify the discriminator factor between the proteins.

Bingyan Wei
Tao Zhang
Cai-Guang Yang
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-16
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Chen and colleagues report that the third enzyme in the oxidative pentose phosphate pathway (PPP), 6PGD, controls cancer cell proliferation by regulating LKB1–AMPK signalling. Inhibitors of 6PGD decrease tumorigenesis in mouse xenografts.

Ruiting Lin
Shannon Elf
Jing Chen
Research19 Oct 2015
Nature Cell Biology

Volume: 17, P: 1484-1496
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Mobile tet(X3) and tet(X4) genes are identified on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated from humans, meat for consumption and animals that confer resistance to tetracyclines, including tigecycline, eravacycline and omadacycline.

Tao He
Ran Wang
Yang Wang
Research27 May 2019
Nature Microbiology

Volume: 4, P: 1450-1456
Research on flipped classrooms in foreign language teaching in Chinese higher education

Wen Kong
Di Li
Quanjiang Guo
ReviewsOpen Access23 Apr 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-14

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CT-based radiomics and deep learning models for predicting thyroid cartilage invasion and patient prognosis in laryngeal carcinoma

Compact RNA editors with natural miniature Cas13j nucleases

Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome

Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity

Programmed genome editing by a miniature CRISPR-Cas12f nuclease

Development of a versatile nuclease prime editor with upgraded precision

Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Research on flipped classrooms in foreign language teaching in Chinese higher education

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