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Showing 1–3 of 3 results
Advanced filters: Author: Quentin Bayard Clear advanced filters

  • Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors analyze three commonly used methods and highlight relative advantages and disadvantages of each method in the context of operational challenges, bioinformatic analyses and biological discoveries.

    • Yixing Dong
    • Chiara Saglietti
    • Elo Madissoon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.

    • Quentin Bayard
    • Léa Meunier
    • Eric Letouzé
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmental exposures and endogenous cellular processes.

    • Eric Letouzé
    • Jayendra Shinde
    • Jessica Zucman-Rossi
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13