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Showing 1–6 of 6 results
Advanced filters: Author: Quentin Gouil Clear advanced filters

  • Here the authors reveal that a neomorphic mutation in chromatin protein SMCHD1 enhances SMCHD1-mediated gene silencing, including at the FSHD disease-relevant locus, while depleting SMCHD1-mediated chromatin interactions, suggesting these SMCHD1 functions are unlinked.

    • Andres Tapia del Fierro
    • Bianca den Hamer
    • Marnie E. Blewitt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Small RNAs, not mRNAs, are the real messengers when it comes to long-distance communication.

    • Quentin Gouil
    • Mathew G. Lewsey
    News & Views
    Nature Plants
    Volume: 7, P: 2-3

  • This analysis leverages experimentally sequenced data and in silico mixtures to simulate transcript expression differences, which enables a performance assessment of long-read tools developed for isoform detection, differential transcript expression analysis and differential transcript usage analysis.

    • Xueyi Dong
    • Mei R. M. Du
    • Matthew E. Ritchie
    Research
    Nature Methods
    Volume: 20, P: 1810-1821

  • Parents transmit both genetic and epigenetic information to their offspring, with maternal effect genes being critical regulators of the offspring epigenome. Here they show that maternally deposited SMCHD1 has long-lasting effects on Hox gene expression and vertebral patterning during post-implantation development.

    • Natalia Benetti
    • Quentin Gouil
    • Marnie E. Blewitt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source of ESCs and show nucleosome remodelers Smarcc1 and Smarca4 create a nucleosome-free promoter region prior to the establishment of silencing.

    • Andrew Keniry
    • Natasha Jansz
    • Marnie E. Blewitt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • This study reports a transcriptome atlas of the germinating Arabidopsis embryo at single-cell resolution. It demonstrates that the cells of the embryo transition from a common transcriptional state to cell type-specific states as germination progresses.

    • Lim Chee Liew
    • Yue You
    • Mathew G. Lewsey
    ResearchOpen Access
    Nature Plants
    Volume: 10, P: 1418-1434