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Showing 1–2 of 2 results
Advanced filters: Author: Róisín M. Loftus Clear advanced filters

  • Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.

    • Róisín M. Loftus
    • Nadine Assmann
    • David K. Finlay
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • NK cells are cytotoxic cells that combat tumors and viral infection. Finlay and colleagues show that the effector function of cytokine-activated NK cells depends on glucose metabolism via the citrate–malate shuttle that requires the metabolic regulator Srebp.

    • Nadine Assmann
    • Katie L O'Brien
    • David K Finlay
    Research
    Nature Immunology
    Volume: 18, P: 1197-1206