Nature Search

Inhibition of lipoprotein-associated phospholipase A₂ reduces complex coronary atherosclerotic plaque development

Although increased levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) have been associated with cardiac disease, whether this enzyme has a causal role in the development of atherosclerosis has not been clear. Wilensky et al. now show in a pig model of atherosclerosis that a selective Lp-PLA2 inhibitor reduces progression to complex atherosclerotic lesion formation, an effect that is associated with decreased infiltration of inflammatory cells into the lesions. These results support the use of Lp-PLA2 inhibitors for the treatment of atherosclerotic cardiovascular disease.

Robert L Wilensky
Yi Shi
Colin H Macphee
Research21 Sept 2008
Nature Medicine

Volume: 14, P: 1059-1066
Getting to the core of atherosclerosis

For years, researchers have debated whether the enzyme lipoprotein-associated phospholipase A₂ (Lp-PLA₂), produced by inflammatory cells, is a 'good guy' or 'bad guy' in atherosclerosis. Work in pigs provides strong support for the view that Lp-PLA₂ promotes the formation of atherosclerotic lesions and dangerous, unstable atherosclerotic plaques (pages 1059–1066).

Nancy R Webb
News & Views01 Oct 2008
Nature Medicine

Volume: 14, P: 1015-1016
The prediction of intraocular pressure rise following argon laser trabeculoplasty

S J Keightley
P T Khaw
A R Elkington
Research01 Sept 1987
Eye

Volume: 1, P: 577-580
The African Caribbean eye survey: Risk factors for glaucoma in a sample of African Caribbean people living in London

R P L Wormald
E Basauri
J R Evans
Research01 May 1994
Eye

Volume: 8, P: 315-320
The progress of the visual field in chronic simple glaucoma and ocular hypertension treated topically with pilocarpine or with timolol

R P Crick
R B Newson
C J Bulpitt
Research01 Jul 1990
Eye

Volume: 4, P: 563-571
Management of monocular congenital cataracts

Scott R Lambert
Research01 May 1999
Eye

Volume: 13, P: 474-479
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Struan F A Grant
Gudmar Thorleifsson
Kari Stefansson
Research15 Jan 2006
Nature Genetics

Volume: 38, P: 320-323
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

A K Mandal
H Bagga
A K Nanda
Research23 Jan 2003
Eye

Volume: 17, P: 53-62
Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5–CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus.

Jason Z Liu
Federica Tozzi
Jonathan Marchini
Research25 Apr 2010
Nature Genetics

Volume: 42, P: 436-440
FEW questions, many answers: using machine learning to assess how students connect food–energy–water (FEW) concepts

Emily A. Royse
Amanda D. Manzanares
Chelsie Romulo
ResearchOpen Access13 Aug 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-18
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

Valgerdur Steinthorsdottir
Gudmar Thorleifsson
Kari Stefansson
Research26 Apr 2007
Nature Genetics

Volume: 39, P: 770-775
Argon laser trabeculoplasty in narrow angle glaucoma

P K Wishart
S Nagasubramanian
R A Hitchings
Research01 Sept 1987
Eye

Volume: 1, P: 567-576
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

Julius Gudmundsson
Patrick Sulem
Kari Stefansson
Research01 Jul 2007
Nature Genetics

Volume: 39, P: 977-983
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

Agnar Helgason
Snæbjörn Pálsson
Kári Stefánsson
Research07 Jan 2007
Nature Genetics

Volume: 39, P: 218-225
Preferential survival of wheat haploids over hybrids in a wheat × barley cross

R A Finch
M D Bennett
Research01 Apr 1982
Heredity

Volume: 48, P: 293-298
Mycobacterium abscessus-associated vertebral osteomyelitis in an immunocompetent patient: a rare case report and literature review

Muhammad Z. Moral
Khusboo Desai
James P. Lawrence
ResearchOpen Access31 May 2019
Spinal Cord Series and Cases

Volume: 5, P: 1-4
UK national survey of prophylactic YAG iridotomy

H G Sheth
R Goel
S Jain
Research17 Sept 2004
Eye

Volume: 19, P: 981-984
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

The Myocardial Infarction Genetics Consortium reports results of a genome-wide association study of early-onset myocardial infarction. The study analyzed common SNPs, common CNVs and rare CNVs and identified SNP alleles at three new loci associated with disease risk.

Sekar Kathiresan
Benjamin F Voight
David Altshuler
Research08 Feb 2009
Nature Genetics

Volume: 41, P: 334-341
The National Survey of Trabeculectomy. II. Variations in operative technique and outcome

Beth Edmunds
John R Thompson
Richard P Wormald
Research01 Jul 2001
Eye

Volume: 15, P: 441-448
The relationship between macular cell layer thickness and visual function in different stages of glaucoma

T S Vajaranant
R J Anderson
M Shahidi
Research25 Feb 2011
Eye

Volume: 25, P: 612-618
DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection

I Perlstein
J M Connolly
R J Levy
Research04 Aug 2003
Gene Therapy

Volume: 10, P: 1420-1428
Chemogenetic and Optogenetic Activation of Gαs Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States

Edward R Siuda
Ream Al-Hasani
Michael R Bruchas
Research04 Jan 2016
Neuropsychopharmacology

Volume: 41, P: 2011-2023
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
Amendments and CorrectionsOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1

Search

Inhibition of lipoprotein-associated phospholipase A₂ reduces complex coronary atherosclerotic plaque development

Getting to the core of atherosclerosis

The prediction of intraocular pressure rise following argon laser trabeculoplasty

The African Caribbean eye survey: Risk factors for glaucoma in a sample of African Caribbean people living in London

The progress of the visual field in chronic simple glaucoma and ocular hypertension treated topically with pilocarpine or with timolol

Management of monocular congenital cataracts

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

FEW questions, many answers: using machine learning to assess how students connect food–energy–water (FEW) concepts

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

Argon laser trabeculoplasty in narrow angle glaucoma

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

Preferential survival of wheat haploids over hybrids in a wheat × barley cross

Mycobacterium abscessus-associated vertebral osteomyelitis in an immunocompetent patient: a rare case report and literature review

UK national survey of prophylactic YAG iridotomy

Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

The National Survey of Trabeculectomy. II. Variations in operative technique and outcome

The relationship between macular cell layer thickness and visual function in different stages of glaucoma

DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection

Chemogenetic and Optogenetic Activation of Gαs Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States

Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

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