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Showing 1–4 of 4 results
Advanced filters: Author: R. Clayton Edenfield Clear advanced filters

  • Early studies in patients and animal models have suggested that SARS-CoV-2 can access the reproductive system and could have effects on fertility. In this Perspective, Edenfield and Easley present the evidence for mechanisms of infection of reproductive cells by SARS-CoV-2 and consider the potential for testicular dysfunction in patients who have had COVID-19.

    • R. Clayton Edenfield
    • Charles A. Easley IV
    Reviews
    Nature Reviews Urology
    Volume: 19, P: 116-127

  • Non-human primates, especially the rhesus macaque, provide a good preclinical model for research into male fertility, owing to their physiological and genetic similarities to humans. In this article, the authors examine the value and limitations of using non-human primates in studies to improve understanding of spermatogenesis, reproductive endocrinology and innovations in assisted reproductive technologies.

    • R. Clayton Edenfield
    • Jasper C. Bash
    • Jamie O. Lo
    Reviews
    Nature Reviews Urology
    Volume: 22, P: 756-774

  • Here, the authors explore how environmentally driven changes in the sperm epigenome can mediate paternal contributions to offspring health. They also describe innovations in human stem cell models that can be used to elucidate the paternal origins of health and disease.

    • Katherine W. Greeson
    • Krista M. S. Crow
    • Charles A. Easley IV
    Reviews
    Nature Reviews Urology
    Volume: 20, P: 356-370