The causes of progression from an asymptomatic fi broatheromatous lesion to a high-risk vulnerable plaque are not fully understood, but data suggest that intraplaque hemorrhage could be critical in this process. Here, Jainet al. focus on angiogenesis and intraplaque hemorrhage in atherosclerotic lesion progression. They discuss evidence for the role of antiangiogenic agents in normalizing the immature vasculature and examine the obstacles faced in testing their hypothesis both in preclinical models and in humans.
- Rakesh K Jain
- Aloke V Finn
- Renu Virmani
