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Showing 1–6 of 6 results

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The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

A disease space is constructed from clinical records by embedding all diseases and considering a patient’s space coordinates as a measure of their health state. This measure was associated with 108 genetic loci, on which models were built to predict various morbidities.

Gengjie Jia
Yu Li
Andrey Rzhetsky
ResearchOpen Access22 May 2023
Nature Computational Science

Volume: 3, P: 403-417
Metabolomic and antioxidant characterization of seven Egyptian and Saudi date syrups via GC-MS and UHPLC/MS with sensory bioactive insights

Rabab M. Abdou
Heba A. Fahmy
Mohamed A. Farag
ResearchOpen Access18 Sept 2025
Scientific Reports

Volume: 15, P: 1-18
Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses

Here, Johnson et al show that bacterial pneumonia induces an interaction between the ubiquitin E3 ligase subunit FBX024 and the mitochondrial protein DARS2 to modulate host immune responses.

Benjamin S. Johnson
Daniela Farkas
Rama K. Mallampalli
ResearchOpen Access22 Jul 2024
Nature Communications

Volume: 15, P: 1-16
ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

Neha Gupta
Salah A. Baker
Bernard T. Drumm
ResearchOpen Access19 May 2025
Scientific Reports

Volume: 15, P: 1-19
AAV capsid bioengineering in primary human retina models

Adrian Westhaus
Steven S. Eamegdool
Leszek Lisowski
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

Eva Delbrel
Abdoulaye Soumare
Emilie Boncoeur
ResearchOpen Access18 Dec 2018
Scientific Reports

Volume: 8, P: 1-14