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Showing 1–12 of 12 results
Advanced filters: Author: Rachelle Gaudet Clear advanced filters

  • Protein sequence signatures suggest that eons ago, a bacterial glutamate transporter lost its sodium coupling to make way for a shift to proton coupling. A study now maps this ancient transition in biochemical and structural detail to better understand how secondary transporters control their energetics.

    • Samuel P. Berry
    • Rachelle Gaudet
    News & Views
    Nature Structural & Molecular Biology
    Volume: 32, P: 2377-2379

  • Transporter proteins mediate the import of nutrients and the export of toxins across biological membranes. A new crystal structure of a bacterial ABC transporter reveals an unexpected mechanism for transporter inhibition by its transported substrate.

    • Rachelle Gaudet
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 454-455

  • ABC systems are an important class of transporters involved in human pathologies for which the basis for transport remains poorly understood. Here the authors suggest a molecular basis for ATP-powered vectorial peptide export by the human transporter associated with antigen processing (TAP).

    • Nina Grossmann
    • Ahmet S. Vakkasoglu
    • Robert Tampé
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • Structure and mutagenesis of the colibactin-activating peptidase ClbP reveals a dimer with a substrate-binding transmembrane domain and a conserved polar network in its periplasmic domain that enforces selectivity for d-asparagine prodrug motifs.

    • José A. Velilla
    • Matthew R. Volpe
    • Rachelle Gaudet
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 151-158

  • The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community.

    • Peter A. Meyer
    • Stephanie Socias
    • Piotr Sliz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-mediated diseases.

    • Liying Zhang
    • Charlotte Simonsen
    • Peter M. Zygmunt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • A substrate-guided design strategy generated highly potent inhibitors of the biosynthesis of the genotoxin colibactin by human gut bacteria. These inhibitors also enable a generalizable approach for chemically guided natural product discovery.

    • Matthew R. Volpe
    • José A. Velilla
    • Emily P. Balskus
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 159-167

  • A combination of structural, computational and biophysical tools is used to characterize the bond between tip-link proteins protocadherin 15 and cadherin 23, which have an essential role in inner-ear mechanotransduction; the bond, involving an extended protein handshake, is found to be affected by deafness mutations and is mechanically strong enough to resist forces in hair cells, adding to our understanding of hair-cell sensory transduction and interactions among cadherins.

    • Marcos Sotomayor
    • Wilhelm A. Weihofen
    • David P. Corey
    Research
    Nature
    Volume: 492, P: 128-132

  • Charlotte Sumner and colleagues report that mutations in the ankyrin repeat region of TRPV4 cause Charcot-Marie-Tooth disease type 2C. Their functional studies indicate that the mutations result in increased channel activity.

    • Guida Landouré
    • Anselm A Zdebik
    • Charlotte J Sumner
    Research
    Nature Genetics
    Volume: 42, P: 170-174

  • Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

    • Pardis C. Sabeti
    • Patrick Varilly
    • John Stewart
    Research
    Nature
    Volume: 449, P: 913-918

  • This Review discusses recent findings in transient receptor potential (TRP) channel structural biology and the impact of these findings in drug development and clinical indications. It also addresses the challenges of modulating TRP channels and the need for targeted approaches to minimize potential side-effects due to the multifunctional roles of TRP channels.

    • Ari-Pekka Koivisto
    • Maria G. Belvisi
    • Arpad Szallasi
    Reviews
    Nature Reviews Drug Discovery
    Volume: 21, P: 41-59