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Showing 1–2 of 2 results
Advanced filters: Author: Rachelle R. Olsen Clear advanced filters

  • The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.

    • Marcel A. Dammert
    • Johannes Brägelmann
    • Martin L. Sos
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.

    • Alex H. Wagner
    • Siddhartha Devarakonda
    • Ramaswamy Govindan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11