Haematopoietic stem cells (HSCs) emerge from a specialized population of endothelial cells, but the events that trigger the transition from endothelial to haemogenic fate are still unclear. Keller and colleagues identified Sox17 as a regulator of this transition upstream of the Notch signalling pathway. They showed that Sox17–GFP marks emerging HSCs in embryo development and when differentiating from mouse embryonic stem cells.
- Raedun L. Clarke
- Amanda D. Yzaguirre
- Gordon Keller
