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Showing 1–8 of 8 results
Advanced filters: Author: Raffaele Ieva Clear advanced filters

  • Many proteins destined for the inner mitochondrial membrane are imported via amino-terminal targeting sequences that are subsequently cleaved. Ieva et al.identify an alternative mechanism for mitochondrial protein import that depends on a carboxyl-terminal targeting sequence.

    • Raffaele Ieva
    • Anna K. Heißwolf
    • Nikolaus Pfanner
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

    • Sonya Hessey
    • Abigail Bunkum
    • Mariam Jamal-Hanjani
    ResearchOpen Access
    Nature
    Volume: 653, P: 911-922

  • The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon holo-complex, LptDEMY, uncovering conformational translocon state transitions that might explain how LPS is assembled at the outer membrane surface.

    • Haoxiang Chen
    • Axel Siroy
    • Raffaele Ieva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Here, the authors identify a third component of the outer membrane LPS translocon in Escherichia coli called LptM. Biochemical analysis and structural modelling reveal that LptM binds the LPS translocon by mimicking its native substrate, so stabilising an active conformation of the complex.

    • Yiying Yang
    • Haoxiang Chen
    • Raffaele Ieva
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Few tools are available to identify active membrane proteins within their native lipid environment. Here, Gold et al. report on a strategy that can be used for site-specific labelling of membrane proteins via electron cryotomography.

    • Vicki A.M. Gold
    • Raffaele Ieva
    • Werner Kühlbrandt
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-9

  • Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

    • Jeffrey V. Lazarus
    • Henry E. Mark
    • Ming-Hua Zheng
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 60-78

  • Osteosarcoma is a tumour with a highly complex genome, which hampers the identification of driver genes. Using a model of murine mesenchymal stem cells (MSCs) with deficient p15Ink4b, p16Ink4a, or p19Arf that transform earlier compared to wild-type MSCs, the authors demonstrated that loss of p16Ink4a is a driver of osteosarcomagenesis. This can be exploited with a CDK4/CDK6 inhibitor, as osteosarcoma cells showed sensitivity to palbociclib which might be used as a novel therapeutic option.

    • Natasja Franceschini
    • Raffaele Gaeta
    • Judith V. M. G. Bovée
    ResearchOpen Access
    Laboratory Investigation
    Volume: 102, P: 391-400