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Showing 1–2 of 2 results
Advanced filters: Author: Raffaella Iurlaro Clear advanced filters

  • LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoting the presence of protumoral macrophages and thatLIF inhibition, via neutralizing antibodies, promotes T cell infiltration and synergizes with immune checkpoint inhbitors resulting in tumor regression and immunological memory.

    • Mónica Pascual-García
    • Ester Bonfill-Teixidor
    • Joan Seoane
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The use of CSF for diagnosis of metastatic brain tumors could be of clinical and patient benefit. Here the authors undertake a single-cell RNA analysis of CSF and brain to determine whether the phenotype in the CSF is reflective of the phenotype in the tumor.

    • Carlota Rubio-Perez
    • Ester Planas-Rigol
    • Joan Seoane
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10